I purchased this methylated-B after my naturopath suggested it when I tested positive for MTHFR markers. The difference it has made has been astronomical. I spend hundreds of dollars a month on supplements to deal with Chronic Fatigue Syndrome, Fibromyalgia, thyroid and adrenal exhaustion. I follow the Myhill protocol, but I occasionally swap products out to see if something else works better. I swapped out my B-complex with folic acid for the Methyl-Guard and noticed a difference within a week. If I have the energy to clean my house, something magical is happening! As an added bonus, which I was not expecting, my fingernails have shown dramatic improvement. Around the time I started taking it, I had my gel nails removed and once the brittle nails grew out, my nails have grown in strong, curve down instead of flaring out, and no longer have ridges. As a lifelong nail biter, this amazed me...until I realized that my anxiety has abated enough to stop gnawing on my nails. I only wish I had discovered this supplement 10 years ago. It has made that much of a difference. Read more

Great product! I have multiple mutations in the MTHFR, CBS, and MAOA genes. I've been taking these (also green coffee) for a week now and I feel like a new person! I have all day energy, much less irritability, less anxiety, less depression, and more mental clarity! This might be my first ever subscribe and save product! :) Read more

I have taken Methyl CPG and other methylated supplements and wasn't sure how good or bad they were until I tried Thorne's methylguard plus. I can actually feel a difference. More energy and healthier overall feeling. It's pretty amazing. I wouldn't have believed it without trying it myself. I'll never switch again. This is the winner for me. Read more

At the suggestion of my MD, both my husband andI have been taking this twice per day for a couple of months. I have to admit, you "pee" like a horse (LOL) but, according to my doctor, that is part of the detoxification. I actually feel GREAT!!! I will continue to take this. Read more

I have MTHFR genetic mutation. I found this product from a link in an online article written by a physician recommending it. Folate is better than folic acid for people with this genetic mutation. I take 2 a day and my energy level has improved so much! No more lethargic afternoons. :) I have been feeling really great snce I started these a few months ago. Read more

I have taken 2-3 of these per day for my MTHFR homozygous mutation and Hashimoto's Thyroiditis for about three years now.I have tried to find a lower-priced option, but there isn't one. You simply need the quality and quantity of bioavailable vitamins available in this supplement if you have the double-mutation.I recommend starting with one cap per day, and going up to two. After a few months at two, if you still feel energy levels and other symptoms could improve, try three. I have found that if I take two caps about four days per week and three caps about three days per week, I seem to sit at the right level, without going overboard into anxiety and headaches. Read more

My brother struggled with depression for years and a friend recommended these. He is noticeably happier and says he has more energy! Read more

listen to the other reviews. start by taking 1 and work your way up to the recommended dose of 3 over a couple of weeks. don't try to be a hero. if I take these after 12 PM, I wake up in the middle of the night and can't sleep. if I get them all down by 9 AM, I feel great during the day and have no sleep issues the following evening. Read more

I cannot recommend this lovely product highly enough, very fast shipping I cannot send enough thanks or recommend you highly enough. Over the moon with my experience! Read more

I have the MTHFR gene so this form of B vit is great for me. I actually feel the difference from taking a regular B vit to this methyl type which is better absorbed for us folks with MTHFR gene mutation. Well packaged and undamaged. Read more

Do not buy this!! I used it for just over 2 months and the high dosage of riboflavin caused damage to cells in my body and caused severe eye floaters that I am left with for the rest of my life!! This should be taken off the market as it is actually damaging to health! Read more

Very good product by trusted manufacturer Have used for several years. I am taking it to fend off possibility of Alzheimers (history in family). So far, so good! Also take in conjunction with Thorne Basic B and Solgar Methylcobalamin 1000mcg - they work together. Read more

Wonderful product that has changed my life! Read more