I found out recently that I am compound heterozygous for the MTHFR mutation. Research indicated I might need activated B6, along with activated folate and B12, so decided to try this brand of B6. Initially, B6 is the only activated B-vitamin I took. I was surprised to notice that within 2 weeks of taking this B6, my anxiety level was reduced tremendously and a muscle in my jaw that had been in a knot for over 20 years, relaxed. I mean, this is the only change I made in that time frame....taking activated B6. So, I am quite happy with my results from taking activated B6. Read more

I began this supplement and woke next day feeling different, better. I had recently discovered I've been anemic for the last year and a half (have MTHFR) without realizing it. My symptom of 'difficulty walking' disappeared overnight. I did not know that was a primary symptom of B6 deficiency. It is so much easier to get around every day and not have to think and effort about every single step and be anxious that I might trip, fall or run into something because of my difficulty maneuvering! What a relief! Thank you! Read more

After finding out activated p5p cures trigger finger I decided to give it a shot. My hands were just short of being totally incapacitated by pain and inability to bend my fingers without them locking into the bent position. I'm 59 and an engineer. My hands are crucial to my livelyhood. I started taking 2 in the morning and 2 at night. In only 1 week my hand pain began dissappearing, in 3 weeks they were no longer locking up with simple use. Now I'm over a month and they haven't locked up a bit even with heavy gripping and mechanical use. I lived with pain for over a year, now only a month later I have full use again. Love this stuff. Non toxic and does the job perfectly! Read more

These are seriously a necessity in my life now. I take one every morning with my Wellbutrin, and I think I'd be better off going without my antidepressant than without this! Read more

A year after taking the product, I noticed a numbness in my feet which evolved into a difficulty in even putting on shoes and even a car accident. It look tremendous amount of troubleshooting to finally realize that it was because of toxic vitamin B6 plasma levels due to this supplement. It took a full year for this to build up in my system - google it and you will see that this is not uncommon. I wish I had known this was a thing. I know that this sounds crazy, but please research this and keep this in the back of your mind if you use this type of supplement. High levels of B6 can cause neuropathy! This is 3000% of the daily recommended dosage. Read more

P5P b6 has helped me break my addiction to Xanaxfor sleep. I take b6, boron, 2 magnesium citrate when I’m ready for sleep. I honestly never thought I could sleep without Xanax. In one week I was off this drug. I had read from The Health Beat that as you get older you need extra B6 so I ordered, I noticed when I took B6 at night I could fall asleep. If during the night I’m awake I take an extra boron. I’m over the moon that I’m off this drug since it causes dementia. Pure Encapsulation is a clean product and my first choice. Read more

Let me just say this product is the best to give my son. He has to take 7 50mg tablets a day, due to a rare b6 enzyme deficiency that causes him to have seizures. It’s called PNPO, this has stopped the 45 minutes seizures and he’s been seizure free for over a year now and this has gotten him off taking 6ml of keppra a day that was increasing monthly. He’s 2 years old, thus making it easier to mix being in capsule form. Read more

I combine this with zinc from pure encapsulations and it truly helps my son with ADHD. Read more