Adding a 30-second rinse with LISTERINE Antiseptic Mouthwash to your morning and nighttime routines is all it takes to get 24 hour protection against germs that cause plaque and gingivitis. Was shown in a clinical study to reduce 52% more plaque and 21% more gingivitis than brushing and flossing alone. Is the only nationally branded antimicrobial mouthwash to receive the ADA Seal of Acceptance for fighting plaque and gingivitis. Has over 100 years of safe use and 50 years of research, making it the most widely used and extensively researched mouthwash in the U.S.